"oncology" Post in this tag
RET gene disease
MEN2(PTA→parathyroid,thyroid,adrenal)
gain of function mutation
Hirschsprung disease
loss of function mutation
oncology
endocrinology
Apr 26, 2019, 7:53 AM
HirotoShishido
AFP↑ 5 diseases
AFP↓ 2 diseases
☆accurate dating is crucial for determining whether levels of AFP are abnormal for gestational age
synthesized in fetal liver, GI tract, and yolk sac(early gestation only)
↑
hepatocellular carcinoma(including hepatoblastoma)
endodermal sinus(yolk suc) tumor
mixed germ cell tumor
ataxia telangiectasia(血管拡張性失調症 leads to lymphoma)
neural tube defect
↓
21 trisomy
18 trisomy(Edward)
biochemistry
oncology
UWorld
Apr 26, 2019, 7:49 AM
HirotoShishido
monoclonal antibody against EGFR
clinical indication
only effective for tumors with ☆wild-type (normal) KRAS
Tumors with KRAS-activating mutations are resistant to anti-EGFR agents
oncology
immunology
UWorld
Apr 18, 2020, 2:13 AM
HirotoShishido
the difference of mechanism between paclitaxel and vinca alkaloids
paclitaxel(TAXanes)→ ☆hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down(anaphase cannot occur)
(TAX STABILIZE the society)
vinca alkaloids→ bind β-tubulin and ☆inhibit microtubule polymerization →prevent mitotic spindle formation(M phase arrest)
pharmacology
oncology
Dec 24, 2019, 10:25 PM
HirotoShishido
the difference of pulmonary fibrosis caused by bleomycin and busulfan
bleomycin→ in weeks or months
busulfan→ at least in 4 years(had FAN and come late)
oncology
pharmacology
Oct 27, 2019, 4:30 AM
HirotoShishido
antitumor antibiotics which induce
free radicals
bleomycin
doxorubicin (can be treated with dexrazoxane, chelating agent to block the formation of iron associated free radicals)
oncology
pharmacology
Oct 26, 2019, 9:39 PM
HirotoShishido
topoisomerase inhibitors for neoplasm
topoisomerase Ⅱ
etoposide
teni(2)poside
→testicular cancer, SCLC, leukemia, lymphoma
topoisomerase Ⅰ
I(1)rinotecan→colon cancer
topotecan→ovarian cancer, SCLC
oncology
pharmacology
Sep 29, 2019, 5:32 AM
HirotoShishido
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